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KMID : 0606920210290040445
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Biomolecules & Therapeutics
2021 Volume.29 No. 4 p.445 ~ p.451
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Salicylamide Enhances Melanin Synthesis in B16F1 Melanoma Cells
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Ito Yusuke
Sato Kazuomi
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Abstract
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Salicylamide, a non-steroidal anti-inflammatory drug (NSAID), is used as an analgesic and antipyretic agent. We have previously shown that several NSAIDs have anti-melanogenic properties in B16F1 melanoma cells. In contrast, we have found that salicylamide enhances melanin contents in B16F1 melanoma cells; however, the underlying mechanism is not known. Therefore, we investigated the mechanism through which salicylamide stimulates melanogenesis. Interestingly, salicylamide enhanced diphenolase activity in a cell-free assay. Western blotting and real-time RT-PCR revealed that salicylamide increased tyrosinase expression via transcriptional activation of the Mitf gene. Together, our results indicate that salicylamide could be used as an anti-hypopigmentation agent for skin and/or hair.
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KEYWORD
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Salicylamide, Melanogenesis, Tyrosinase, Melanoma, Mitf
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